Endocrine Abstracts

Background and aims: Hypoglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hypoglycemia have not been extensively studied. The aim of this study was to assess the impact of insulin-induced hypoglycemia on the platelet activity, endothelial dysfunction and the physiological anticoagulant level in patients with DM1.Research design and methods: We studied seve...

Heterogeneity of diabetes mellitus (DM) determines difficulties in the diabetes type verification and further treatment. With this regard, in 2019 WHO published a new classification of DM with categories: “hybrid types of diabetes” and “unclassified diabetes” intended for use in clinical practice.Aim: To investigate the heterogeneity and clinical features of DM in young adult patients with an unspecified type of diabetes.<p cl...

Background: Werner syndrome is a rare autosomal recessive disease caused by a mutation of the DNA helicase gene (WRN), characterized by the premature onset of multiple age-related disorders.Objective: To describe unusual multiple endocrine and metabolic disorders in three unrelated clinical cases of Werner syndrome.Methods: Three patients with obvious clinical features of premature ageing were referred to an endocrinologist due to ...

Background and aims: Hypoglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hypoglycemia have not been extensively studied. During hypoglycemia, a wide spectrum of physiologic responses are activated that could have potential vascular biological effects. To date, the role played by catecholamines, the sympathetic nervous system, and neuroendocrine hormones on activating adhesion m...